Chronic Graft Vs Host Disease Is The Strongest Predictor Of Outcome After Reduced Intensity Conditioning Stem Cell Transplantation In Chronic Lymphocytic Leukemia and Is Associated With Pretransplant B Cell Characteristics
Saad Sirop Kenderian, Ruchi G. Sharma, Mrinal M Patnaik et al.
Key Points:
To validate Dana Farber (DF) model and also identify additional predictors of outcomes after SCT
Higher scores on DF prognostic model less likely to develop cGVHD
Rates of cGVHD for ZAP 70 positive and ZAP70 negative patients 50% and 92%, respectively (p=0.03) post RIC-SCT
Implications:
Post transplant cGVHD most significant predictor for OS and DFS.
Pretransplant DF prognostic score and ZAP70 status can predict subsequent cGVHD.
View the original abstract on the ASH website.
