OSU-T315, An Integrin-Linked Kinase (ILK) Inhibitor, Induces Apoptosis By Targeting B Cell Receptor and CD49d Mediated AKT/ERK Activation In Chronic Lymphocytic Leukemia Cells
Ta-Ming Liu, YongHua Ling, Mitch A. Phelps et al.
Key Points:
OSU-T315 inhibits down-stream AKT and ERK signaling cascades without affecting proximal BCR or focal-adhesion signaling.
External stimuli through BCR or CD49d -> triggers survival signal thereby protects CLL from ankoisis via AKT/ERK activation; path inhibited by OSU-T315.
OSU-T315 mediated cell death Caspase dependent.
In TCL1 mouse model drug improved total WBC and decreased splenomegaly.
Implications:
- Dual-targeted approach potential therapeutic development in CLL.
View the original abstract on the ASH website.
