A Cyclopropane-Derived Stable Analog Of Fd-895 Induces Apoptosis and Inhibition Of mRNA Splicing In Lymphoma and Chronic Lymphocytic Leukemia: A Novel Therapeutic Approach
Deepak Kumar, Manoj Kumar Kashyap, Ide Spaanderman et al.
Key Points:
RNA splicing implicated in tumorigenesis.
Spliceosome inhibitors (FD-895 and Pladienolide B (PLAD-B)) with improved biochemical stability potent pro-apoptotic activity in CLL.
Intron retention and development of apoptosis.
Expression of alternative spliced pro-apoptotic forms.
Implications:
- Spliceosome inhibitors can be used for cancer treatment.
View the original abstract on the ASH website.
