Interrogation Of Signaling Networks In B Cell Malignancies To Improve Classification Of Patient Subsets For Targeted Therapy
Obidi1 J, Burke P, Goswami T et al.
Key Points:
This study attempted to corroborate signaling profiles with clinical features.
AKT signaling in malignant cells contrasted significantly with normal B cells.
Two distinct signaling profiles identified in DLBCL cell lines.
Several cell lines depicted absence of functional NFκB activity secondary to increased negative regulation.
Implications:
- Profiling of signaling network activities represents promising approach to molecularly classify DLBCL and CLL subtypes.
View the original abstract on the ASH website.
