Alloreactive T Cell Clonotypes Identified By In Vitro Mixed Lymphoid Reaction and High-Throughput Sequencing Exhibit Increased Frequency In Peripheral Blood Samples From Patients Following Allogeneic Hematopoietic Cell Transplantation For Chronic Lymphocytic Leukemia
Aaron C. Logan, Mark R. Krampf, Mark Klinger et al.
Key Points:
In vitro study to identify alloreactive (AR)/GVL T cells.
Studied mixed lymphocyte reactions (MLRs) between recipient CLL cells and donor T cells.
Persistence of adoptively transferred candidate AR/GVL clones who has undergone RIC allo-HCTc correlate with likelihood of maintaining clinical remission beyond 2 years.
Implications:
- Failure to adoptively transfer AR/GVL clonotypes associated with early treatment failure.
View the original abstract on the ASH website.
