Next-Generation High Throughput Sequencing Analysis In The Search Of Infectious Pathogens In Suspect Lymphoproliferations
Daniela Hoehn, Jordan M. Schecter, David Hirschberg et al.
Key Points:
Investigate novel lymphotropic pathogens as causative agents of lymphomagenesis.
Of 49 lymphoma patients 10 are CLL/SLL.
Sequencing done in 46 cases and microbial sequences detected in 5 specimens (9%) and in rest of 41 cases no non-human genetic material identified.
Implications:
- No novel lymphotropic microbial pathogens identified in non-EBV associated T- and B-cell lymphoproliferations, which argues against clonal infectious etiology.
View the original abstract on the ASH website.
