MYC Translocations In Mature B-Cell Neoplasms: Single, Double, Triple and Quadruple Hit Lymphoma
Sabine Denzel, Tamara Alpermann, Wolfgang Kern et al.
Key Points:
Subclassification for mature B-cell neoplasms based mainly on cytomorphological features.
Large cohort of patients with mature B-cell neoplasms and MYC translocation with respect to phenotypic presentation and additional cytogenetic abnormalities.
CLL accounted for 20.1% of study population.
In CLL MYC was translocated to other loci/genes in 62.8% of cases unlike in ALL, Burkitt lymphoma and other mature B-cell neoplasms.
CLL showed most frequently single hit lymphoma (93%)
Abnormalities in addition to MYC translocation in CLL (13q), (del(11q), (del(17p) and +12 unlike other matured lymphomas.
Implications:
- MYC translocations can occur as secondary events in CLL but different from other lymphatic malignancies with respect to translocation partners and additional chromosome aberrations.
View the original abstract on the ASH website.
