Enalidomide Promotes The Expansion Of CD8 T Cells With An Effector Memory Phenotype In a Murine Xenograft Model Of Chronic Lymphocytic Leukemia
Rita Simone, Sonia Marsilio, Piers E.M. Patten et al.
Key Points:
Action of lenalidomide CLL primarily indirect, affecting non-malignant cells particularly T lymphocytes.
Administration of lenalidomide leads to greater engraftment of human hematopoietic cells in alymphoid mice particlarly CD8+ effector memory T cells.
In absence of prior T-cell activation, CLL T cells appear to support better CLL B-cell growth.
Implications:
- Lenalidomide generates cytolytic T cells and B-cell expansion by activation of autologous T-cell compartment.
View the original abstract on the ASH website.
