The Influence Of Anti-HLA Antibodies On Engraftment and Donor’s Chimerism Following Allogeneic Hematopoietic Stem Cell Transplantation From HLA-Mismatched Unrelated Donors
Markiewicz M, Koclega A, Mizia S et al.
Key Points:
Role of anti-HLA Abs before allo-HSCT from HLA-mismatched unrelated donors and impact on engraftment.
In 32 pts anti-HLA abs before allo-HSCT detected.
In 49 pts anti-HLA abs were detected after allo-HSCT.
No graft failure observed.
Presense of anti-HLA abs before allo-HSCT associated with decrease of post-transplant donor’s chimerism.
Implications:
- In mismatched allo-HSCT recipients anti-HLA Abs only associated with post-transplant full donor’s chimerism, not with engraftment or graft failure.
View the original abstract on the ASH website.
