High Dose Cyclophosphamide (HDCy) Post Stem Cell Transplant (SCT) Following High Dose Melphalan (HDMel) Based Conditioning As a Dual Strategy For Chemotherapy Dose Intensity and Graft Versus Host Disease (GvHD) Prophylaxis In Matched and Mismatched allo-SCT
Nath R, Cerny J, Ramanathan M et al.
Key Points:
Outcomes for patients who recived HDMel-based conditioning followed by HDCy post SCT.
All patients recived fludarabine (25mg/m2 x5) HDMel (100-140 mg/m2) and thiotepa (5-10 mg/kg).
aGvHD (grade 2-4) 38.9%, cGvHD 16.6%. Day 100, 6 month and 1 year survival was 100%, 87% and 80%.
Implications:
- HDCy post HDMel conditioning feasible in matched and partially matched allo SCT recipients.
View the original abstract on the ASH website.
