TP53 Disruption and Telomere Instability In Chronic Lymphocytic Leukemia
Pagès M, Veronese L, Combes P et al.
Key Points:
TP53 gene mutations and/or by17p deletions associated with poor survival and chromosomal instability in chronic lymphocytic leukemia (CLL).
Changes in main telomeric parameters and integrity, associated with TP53 mutations and 17p deletions and their prognostic value.
Low TPP1 and high RAP1 expression identify subsets of TP53 wild type patients with significantly shorter TTP.
Implications:
- TP53 disruption may play major role in telomeric and chromosomal instability in CLL.
View the original abstract on the ASH website.
