A Complex Molecular Network
Berg V, Vartak N, Claus R, et al.
Key Points:
Investigators intended to determine role, regulation and precise molecular function of palmitoylated-CD95 in CLL
De-palmitoylating enzymes LYPLA1 and LYPLA2 significantly over-expressed on gene and protein level in primary CLL cells
Interaction between LYPLA1/LYPLA2 and CD95 essential for proper apoptotic signaling
Precise localization of CD95 on plasma membrane might be responsible for the effects observed on CLL cells and other tumor cells.
Implications:
Study identified novel interaction partners of CD95
Inhibition of de-palmitoylating enzymes can possibly restore CD95 apoptotic signaling and thereby improve immunogenicity of CLL cells.
View the original abstract on the ASH website.
