Aberrant Splicing In Patients With AML Is Associated With Over- Expression Of Specific Splicing Factors
Adamia S, Bach C, Pilarski P et al.
Key Points:
Expression levels of 24 core splicing factors (SFs) involved in splicing reactions in cells from 30 AML patients compared to 10 NDs.
Authors identified three, U2AF2, PTBP, and SFRS12, upregulated in AML samples.
Authors detected increased expression of U2AF2 and PTBP at protein level.
Implications:
- Overexpression of splicing factor genes may alter splicing, accelerate malignant cell growth in vitro and possibly in vivo.
View the original abstract on the ASH website.
