Concomitant, T-Independent TLR9-Mediated and BCR-Mediated Activation Provides Signals For Optimal Telomerase Induction In Chronic Lymphocytic Leukemia Cells Regardless Of IGHV Mutation Status
Damle R, Temburni S, Andersen R et al.
Key Points:
Study authors assessed TLR9-driven or BCR + TLR9-driven CLL B-cell activation.
Findings: TLR activation with with ODN2006 induced apoptosis within 16 hours in 6/12 CLL cases.
BCR activation upregulates telomerase activity only in Ig V-unmutated CLL.
TLR9-mediated activation induced telomerase activation in all CLL cases.
Implications:
- Stimulation of CLL cells via TLR9 and BCR receptors impacts telomerase activity in all patients studied.
View the original abstract on the ASH website.
