Influence Of Antithymoglobulin Doses On The Outcome Of Hematopoietic Stem Cells Transplantations After a Flu-Bu2 Conditioning Regimen: A Retrospective Study On 168 Consecutive Patients
Cornillon J, Balsat M, Cabrespine A et al.
Key Points:
Retrospective study investigated role of two different ATG regiments on incidence of non-relapse mortality (NRM) on patients who received a fludarabine-busulfan RIC AHSCT.
168 patients enrolled: RIC (Fludarabine 150 mg/m² and Busulfan for 2 days); ATG (Thymoglobuline®) 2.5(ATG1) or 5(ATG2) mg/kg/day.
Cumulative incidence of cGvHD higher in ATG1 group, but not statistically significant.
Implications:
- Two days of ATG decrease NRM independently of disease, source of donor, graft or GvHD incidence.
View the original abstract on the ASH website.
