ZAP70 Methylation Is An Independent Prognostic Biomarker For Front Line Therapy Of Chronic Lymphocytic Leukemia: Results From The UK LRF CLL4 Trial
Parker A, Gregory B, Davis Z et al.
Key Points:
Authors proposed measurement of ZAP70 methylation as alternative biomarker for front line therapy of CLL.
416 samples obtained and analysed for ZAP70 methylation comparing Chlorambucil(C) with Fludarabine alone (F) or in combination with Cyclophosphamide(FC).
PFS or OS: no significant difference seen between C334L and C334Int groups.
Implications:
- Hypermethylation of ZAP70 has independent prognostic value and patients who possesS such value display superior outcome after first line chemotherapy.
View the original abstract on the ASH website.
