A Multicentre Retrospective UK Study Detailing Onset Of GvHD, Responses To Treatment and Outcome After Donor Lymphocyte Infusion Following Haemopoietic Stem Cell Transpantation: Rates Of GvHD Are High But Death From GvHD Infrequent.
Scarisbrick J, Bhons M, Dignan F et al.
Key Points:
Authors investigated NIH type, severity, treatment and response rates of GvHD following donor lymphocyte infusions(DLI).
58 patients who received DLI were included in this study.
Oral prednisolone used as a first line treatment of aGVHD in all 16 patients.
For 5 patients who progressed on prednisone, 2nd line therapy with tacrolimus.
OS in patients with aGVHD and cGVHD 63% and 74% respectively compared to 12/15 (80%) without GVHD.
Implications:
Patients receiving DLI after HSCT developed: GVHD in 74% of cases, 24% severe.
Treatment of GvHD with steroids very successful in 61% of cases.
View the original abstract on the ASH website.
