Regulation Of Microrna Mir-21 Expression By ZAP-70 Protein In Chronic Lymphocytic Leukemia
Crespo M, Carpio C, Carabia J et al.
Key Points:
Aberrant expression of miR-21 associated with refractoriness to fludarabine and poor overall survival.
Authors investigated relationship between ZAP-70 protein and miR-21 in CLL patients.
After stimulation of co-cultured primary CLL cells and bone marrow stromal cells with CD40 and TLR-9 authors observed 3.6 fold induction in miR-21 expression with low or high expression of ZAP-70.
Stimulation of BCR receptor in Ramos-GFP cells induced the expression of miR-21.
Implications:
- Participation of ZAP-70 protein in regulation of miR-21 expression could clarify the role of ZAP-70 in miR-21 induction in CLL.
View the original abstract on the ASH website.
