Thymidine Kinase Levels Correlate With Prognosis In High Grade Lymphoma, and Can Discriminate Patients With a Clinical Suspicion Of Low Grade To High Grade Transformation
Gatt M, Goldschmidt N, Friedman M et al.
Key Points:
Authors used new TK chemiluminescence immunoassay to detect serum TK1 levels in patients with hematologic neoplasms.
Serum TK1 levels correlated with baseline clinical and laboratory parameters and OS.
194 patients, most with lymphoid neoplasms DLBCL and low grade NHL.
TK level of >14.1 u/L had sensitivity of 95% and specificity of 76% for having a low to high grade lymphoma transformation.
Implications:
- TK levels useful in assessing prognosis, especially in high grade lymphomas.
View the original abstract on the ASH website.
