Graft Failure In Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation.
Olsson R, Berggren D, Ringden O et al.
Key Points:
Risk factors for graft failure in first RIC allo-HSCTs investigate.
357 patients selected for study.
GvHD prophylaxis using cyclosporine A in combination with mycophenolate mofetil: higher incident of graft failure compared to regimen with CSA and MTX (18% vs. 5%; P<0.01).
Patients with non-malignant disorders (26% versus 2%; P<0.01) and solid tumors (20% vs. 2%; P<0.01) had increased risk of graft failure compared to acute leukemia.
Dose of total nucleated cell important with less graft failures when TNC dose was >10 x 108/kg.
Implications:
Graft failure augmented in male recipients, patients with non-malignant disorders.
GVHD prophylaxis, HLA mismatch and TNC dose important risk factors.
View the original abstract on the ASH website.
