Microenvironmental Factors and The Role Of Tumor Necrosis Factor Receptor Type 1 (TNFR-1) In Chronic Lymphocytic Leukemia
Duerr C, Schulz A, Ohl S et al.
Key Points:
In this study authors evaluated role of Tumor Necrosis Factor Receptor Type 1 (TNFR-1) on survival of CLL-cells.
Authors found: Tumor Necrosis Factor Receptor Type 1 (TNFR-1) significantly upregulated in malignant B-cells under survival-maintaining cultivation as well as in CLL serum.
Implications:
- TNFR-1 signaling involved in CLL cell survival and might be promising target for biological therapy.
View the original abstract on the ASH website.
