NFAT2 Is a Critical Regulator Of Anergy Induction In CLL
Märklin M, Heitmann JS, Worbs D et al.
Key Points:
Role of NFAT2 transcription factor in pathogenesis of CLL assessed by knocking out NFAT2 in TCL1 CD19-Cre CLL mouse model.
NFAT2 knock out mice demonstrated more aggressive disease course of CLL with shorter life expectancy.
NFAT2 knock out CLL cells showed significantly altered gene expression of 22 genes associated with B cell anergy.
Implications:
- Absence of NFAT2 causes increased expression of CD38 and ZAP70 on leukemic cells and reduces expression of genes that control acquisition of anergic CLL phenotype.
View the original abstract on the ASH website.
