TP53 Alterations In CLL - Parameters Influencing The Prognostic Impact: A Study On 3,988 Patients
Haferlach C, Dicker F, Jeromin S et al.
Key Points:
Study looked at frequency of TP53 alterations, association with unmutated IGHV gene and impact on survival.
Out of 3988 patients, TP53 alteration observed in 13.2% of patients, 6.7% had both deletion and mutation, while 5.5% harbored TP53mut only and 1.0% a TP53del only.
Unmutated IGHV more strongly associated with patient's harboring both TP53 mutation and deletion.
Independent factors associated with shorter OS according to multivariate analysis are: TP53del (HR: 4.2) TP53mut ≥20% (HR: 2.4), age >60 yrs (HR: 2.6), SF3B1mut (HR: 2.4), and del11q (HR: 2.2).
Implications:
- TP53 deletions had most adverse impact on survival whereas TP53 mutations had significant impact on OS only if mutation burden ≥20%.
View the original abstract on the ASH website.
