Targeting The T Cell Component Of The Tumour Microenvironment In Chronic Lymphocytic Leukaemia; A Potential Therapeutic Strategy
Cuthill KM, Buggins AGS, Chana P et al.
Key Points:
To study role of T-cells in CLL micro environment in promoting CLL cells survival and proliferation authors utilized cyclosporin (CsA) and studied expression of transcription factors in treated and control B-CLL and T cells.
NF-kB(p65) and NFAT-c2 translocation inhibited by mean of 22% & 24% respectively in CLL CD4+ T cells when treated with CsA compared to control. Whereas NFkB(p65) and NFAT-c2 translocation either not or only minimally inhibited in activated CLL B-cells.
Proportion of activated T cells expressing both CD69 and IFN-Υ reduced by 13.2% with CsA whereas no inhibition of CD25 expression demonstrated in activated CLL B-cells.
Implications:
- Previously reported activity of CsA in CLL not due to direct effect on tumor cells instead resulted from inhibition of signals provided by activated CD4+ T cells in tumor microenvironment.
View the original abstract on the ASH website.
