Chronic Lymphocytic Leukemia Cells With Trisomy 12 Home To The Bone Marrow In a CXCR4-Independent Manner and Are Prone To Proliferate In Vitro
Hutterer E, Hinterseer E, Ganghammer S et al.
Key Points:
Study assessed functional interplay of VLA-4 and CXCR4 in CLL carrying trisomy 12 (tri12).
Upregulation of CD49d expression in cohort paralleled by their reduced CXCR4 expression. Frequent CD49d+ in patients with tri12 led to increase homing rates compared to no tri12 CLL. However, homing not affected by presence or absence of tri12 if CD49d status controlled.
Inhibition of CXCL12 or CXCR4 reduces homing of no tri12 CLL cells to bone marrow whereas homing capacity of tri12 CLL cells unaffected.
CXCL12 lead to arrest of no tri12 CLL cells on VCAM-1 by CXCR4 and VLA-4 dependent manner whereas tri12 CLL cells robustly tethered to VCAM-1 without help of chemokines.
Implications:
- These results provides in part mechanistical basis of clinical features of tri12 CLL.
View the original abstract on the ASH website.
