Impact Of The Number Of Prior Treatment
Grigore G, Barrena S, Perez-Andres M, et al.
Key Points:
Study aims to evaluate effect of number of treatment lines received on different normal circulating leucocyte cell populations in advanced-stage treated CLL
PB normal B cells reduced in patients who had received either one or more line of treatment
Therapy-related decreased B-cell mostly due to reduced number of circulating memory B cells
Absolute CD4+ T cells and CD4/CD8 double negative TCRαβ cells significantly lower in patients with >1 line of treatment.
Implications:
Previously treated patients have significantly reduced counts of total and memory (all isotypes) normal B-cell subsets.
CD4+ helper T cells could also be compromised after more than one line of treatment.
View the original abstract on the ASH website.
