The Role Of PRDM1 and Its Interacting Proteins In The Pathogenesis Of Chronic Lymphocytic Leukemia
Shukla A,Chaturvedi N,Joshi S et al.
Key Points:
Identified PR Domain Zinc Finger Protein1 (PRDM1) as one candidate tumor suppressor gene in CLL.
PRDM1/BLIMP1 is transcriptional repressor crucial for terminal differentiation of mature B cells into plasma cells.
PRDM1 expression significantly decreased in CLL cells from poor prognosis.
Expression levels of PRDM1 found to correlate with time to treatment in CLL patients.
Lower expression of PRDM1 associated with shorter time to treatment in CLL.
Increased expression of BCL2, PAX5, EHMT2, SPIB and decreased expression of BCL6, IRF4, BCR, CASP3, pFOS, TP53 and HDAC2 in CLL cells from poor prognosis patients.
Implications:
- PRDM1 a negative regulator of CLL aggressiveness and progression.
Additional Comments:
- These studies warranted additional investigation to elucidate mechanism of PRDM1 mediated CLL progression and to identify therapeutic target.
View the original abstract on the ASH website.
