CMV-Specific CD8+ T-CELL Function Is NOT Impaired In CLL
Raa D,Pascutti F,Garcia-Vallejo J et al.
Key Points:
Increased expression of exhaustion markers PD-1, CD160 and CD244 on CLL-derived total CD8+ T cells.
Significantly lower expression of these markers on CMV-tetramer+CD8+ T cells in CLL patients.
Analyzed functionality of CMV-specific CD8+ T cells.
No differences between CLL patients and age-matched HC as to IFNγ, TNFα and IL-2 production by CMV-tetramer+CD8+ cells.
Fraction of CMV-tetramer+CD8+ T cells producing cytokines also did not differ.
CMV-specific CD8+ T cells from CLL patients as effective as those from HC in killing CMV-peptide-loaded EBV-LCLs at varying effector:target ratios.
Percentages of CD8+T cells forming specific proper IS with CMV-peptide loaded EBV-LCLs comparable in CLL and HC T cells (around 45%).
Implications:
- CMV-specific CD8+ T cells derived from CLL patients have lower expression of exhaustion markers and are functionally intact.
View the original abstract on the ASH website.
