The Landscape Of Gene Mutations In Chronic Lymphocytic Leukemia With Elevated Genomic Complexity
Malek S, Saiya-Cork K, Shedden K et al.
Key Points:
Authors identified 50 CLL-HGC cases with ≥3 acquired genomic copy number aberrations (aCNA) and/or acquired uniparental disomy (aUPD).
Fnctional analysis detected 3 CLL-HGC cases with impaired p53 protein induction following chemical p53 activation and two cases with impaired ATM-Ser-1981 auto-phosphorylation.
Implications:
- CLL-HGC with wild type TP53 not associated with a high-frequency mutated gene; most CLL-HGC with wild type TP53 carry mutations in genes that may have role in CLL genome destabilization.
View the original abstract on the ASH website.
