GLI2 Transcription Factor Modulates CD40 Ligand Expression In Bone Marrow Stromal Cells
Neil MS, Dennison JR, Fernandez-Zapico ME et al.
Key Points:
Role of GLI2 in HS-5 bone marrow stromal cells.
GLI2 can modulate expression of several cytokines including CD40 ligand (CD40L), CCL2, CCL7 and CXCL11.
Analysis of CD40L promoter indicates presence of 3 candidate binding sites for GLI proteins, suggesting modulation mediated by direct interaction with promoter.
Implications:
- Novel mechanism of controlling CD40L in stromal cells in bone marrow microenvironment discovered.
View the original abstract on the ASH website.
