The Novel Proteasome Inhibitor MLN2238 (Ixazomib) Induces Death In CLL Cells In Vitro and Potentiates Lethality Of Fludarabine and The BCL2 Inhibitor At-101
Chitta K, Paulus A, Akhtar S, et al.
Key Points:
Investigators examined anti-CLL properties of MLN2238 to induce CLL cell death and down regulate BCL2.
Concentration dependent decrease in viability detected in CLL cells in response to treatment with MLN2238.
Implications:
- Treatment oF CLL cells with MLN2238 resulted in lethal events in CLL cells, further enhanced by disruption of the BCL2 prosurvival pathway.
View the original abstract on the ASH website.
