STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis
Li P, Rozovski U, Harris D, et al.
Key Points:
STAT3 constitutively activated in CLL cells and promoter of GM-CSFRα gene harbors putative STAT3 binding sites.
Authors hypothesized STAT3 activates GM-CSFRα in CLL cells.
Investigators cloned GM-CSFRα promoter in multiple myeloma cell line MM1 and using luciferase assay identified STAT3 binding activity and 7200 RNA transcripts that co-immunoprecipitated with GM-CSFRα.
GM-CSFRα–bound KAP1 enhanced transcriptional activity of STAT3, whereas GM-CSFRα–bound ISG-15 inhibited nuclear factor-κB pathway.
Implications:
- STAT3 induces transcription of GM-CSFRα, which has distinct, ligand-independent, anti-apoptotic activities.
View the original abstract on the ASH website.
