ONCOmmunity

Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung.

By: G Kayser, A Csanadi, S Kakanou, A Prasse, A Kassem, E Stickeler, B Passlick, A Zur Hausen

Department of Surgical Pathology, Institute of Pathology, University Medical Center Freiburg, Breisacher Strasse 115a, D-79106 Freiburg, Germany.
2014-9-30; doi: 10.1038/bjc.2015.2

Abstract

Background

The metastasis suppressor 1 (MTSS1) is a newly discovered protein putatively involved in tumour progression and metastasis.

Material

Immunohistochemical expression of MTSS1 was analysed in 264 non-small-cell lung carcinomas (NSCLCs).

Results

The metastasis suppressor 1 was significantly overexpressed in NSCLC compared with normal lung (P=0.01). Within NSCLC, MTSS1 expression was inversely correlated with pT-stage (P=0.019) and histological grading (P<0.001). NSCLC with MTSS1 downregulation (<20%) showed a significantly worse outcome (P=0.007). This proved to be an independent prognostic factor in squamous cell carcinomas (SCCs; P=0.041), especially in early cancer stages (P=0.006).

Conclusion

The metastasis suppressor 1 downregulation could thus serve as a stratifying marker for adjuvant therapy in early-stage SCC of the lung.

PMID:25625275