ONCOmmunity

Association of CCND1 gene polymorphism with cervical cancer susceptibility in Caucasian population: a meta-analysis.

By: Mei Yang, Hongmei Zhu, Ting Hu, Shanling Liu, He Wang

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu 610041, People's Republic of China ; Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University Chengdu 610041, People's Republic of China.
2015--; doi:

Abstract

Objective

To study G870A polymorphism in CCND1 gene and the risk of cervical cancer susceptibility in Caucasian population by meta-analysis.

Methods

Search the correlative study of G870A polymorphism in CCND1 gene and cervical cancer susceptibility in PubMed and EMBASE database, and extract the reference data according to the including criteria. We used RevMan 5.2 software to merge the OR value and 95% confidence interval and to perform meta-analysis.

Results

Five case-control studies were enrolled into the analysis, including 1665 patients with cervical cancer and 2511 healthy people as control. It was revealed by meta-analysis that, in the Caucasian population, there was no significant correlation between G870A polymorphism in CCND1 gene and the risk of cervical cancer (G allele vs. A: OR = 1.01, 95% CI = 0.80-1.27, P = 0.95; AA vs. GA + GG: OR = 1.13, 95% CI = 0.98-1.30, P = 0.10; (GA + AA) vs. GG: OR = 1.15, 95% CI = 0.72-1.85, P = 0.55).

Conclusion

G870A polymorphism in CCND1 gene may be uncorrelated with the development of cervical cancer in Caucasian population.

PMID:26550218