ONCOmmunity

The prognostic value of p53 expression for patients with cervical cancer: a meta analysis.

By: Ruoyu Zhou, Chuanyu Wei, Jing Liu, Ying Luo, Wenru Tang

Laboratory of Molecular Genetics of Aging & Tumor, Medical Faculty, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan 650500, China.
2015-2-6; doi: 10.1016/j.ejogrb.2015.10.006

Abstract

Objective

A number of studies have evaluated the association of p53 expression with the cervical cancer clinical outcome, but the results were inconsistent.

Study

Electronic search of PubMed was conducted to select studies. Studies which quantitatively evaluated the relationship between p53 expression and survival of the patients with cervical cancer were chosen, and hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association.

Results

The final meta-analysis contained 11 published studies including 1105 patients. Combined HRs suggested that p53 overexpression has an unfavorable impact on overall survival(OS) [HR=1.672, 95% confidence interval (CI): 1.144-2.444, P=0.008], and Caucasian cervical cancer patients OS[HR=1.942, 95% CI: 1.162-3.245, P=0.011].

Conclusions

p53 expression indicates a poor prognosis for Caucasian people with cervical cancer.