ONCOmmunity

Impact of Body Weight Loss on Recurrence After Curative Gastrectomy for Gastric Cancer.

By: Hidemasa Kubo, Shuhei Komatsu, Daisuke Ichikawa, Tsutomu Kawaguchi, Toshiyuki Kosuga, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
2016-2-7; doi:

Abstract

Background

This study was designed to assess the prognostic role of body weight loss (BWL) after curative gastrectomy for gastric cancer patients.

Patients

We analyzed a total of 102 consecutive patients who underwent curative gastrectomy for stage II or III gastric cancer between 2005 and 2011. Postoperative BWL during the first 6 months in patients was calculated from their hospital records.

Results

Postoperative BWL was significantly higher in patients with tumours in the upper stomach, total gastrectomy, or subsequent recurrence. A postoperative BWL of 12% was the optimal cut-off value, which was strongly associated with subsequent recurrence. Patients with a postoperative BWL of 12% or higher did not have poorer overall survival but did have significantly poorer disease-free survival than patients with BWL of less than 12%. Cox proportional hazard analyses revealed that a postoperative BWL of 12% or higher was an independent prognostic factor of poor disease-free survival.

Conclusion

High BWL after curative gastrectomy is related to recurrence in patients with gastric cancer.