ONCOmmunity

Prognostic Impact of Postoperative C-reactive Protein for Non-small Cell Lung Cancer Following Lobectomy.

By: Shuichi Shinohara, Masakazu Sugaya, Takamitsu Onitsuka, Kazuhiko Machida, Masaki Matsuo, Fumihiro Tanaka

Department of Thoracic Surgery, Chubu Rosai Hospital, Nagoya, Japan musictiger617@gmail.com.
2018-03-14; doi: 10.21873/anticanres.12584

Abstract

Background/aim

C-reactive protein (CRP) is associated with cancer progression; however, the prognostic impact of postoperative CRP remains controversial. The aim of this study was to investigate the prognostic significance of postoperative CRP in patients with resected non-small cell lung cancer (NSCLC).

Patients

A total of 198 consecutive patients with NSCLC that had undergone lobectomy were retrospectively reviewed. CRP was measured on postoperative days 1, 3, and 5. Patients were divided into two groups according to the median of CRP on postoperative day 3 (CRP₃); the high and low CRP₃ groups (n=99, respectively).

Results

Five-year overall survival was significantly higher in the high CRP₃ group than the low CRP₃ (75.3% vs. 86.5%; p=0.016), as was the 5-year recurrence-free survival (62.7% vs. 73.0%; p=0.016). Multivariate analysis revealed that high CRP₃ was associated with a favorable prognosis (hazard ratio(HR)=0.36; p<0.001).

Conclusion

High CRP₃ may be a favorable prognostic predictor in patients with NSCLC following lobectomy.