ONCOmmunity

Associations Between MTHFR Polymorphisms and the Risk of Potentially Malignant Oral Disorders.

By: Thomas Senghore, Yu-Feng Li, Fung-Chang Sung, Ming-Hsui Tsai, Chun-Hung Hua, Chiu-Shong Liu, Min-Feng Hung, Chih-Ching Yeh

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan, R.O.C.
2018-04-19; doi: 10.21873/anticanres.12690

Abstract

Aim

The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs).

Materials

Genotypes of the MTHFR C677T and A1298C polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls.

Results

The C677T T allele-carrying genotypes were significantly associated with a decreased risk of PMODs [odds ratio (OR)=0.62, 95% confidence interval (CI)=0.44-0.86]. Haplotype analysis also indicated that the 677T/1298A haplotype was associated with a decreased risk of PMODs (OR=0.56, 95%CI=0.40-0.80). No significant interaction was observed between MTHFR polymorphisms and lifestyle factors.

Conclusion

Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples.