ONCOmmunity

Biomarkers of Oxidative Stress Associated with the Risk of Potentially Malignant Oral Disorders.

By: Thomas Senghore, Yu-Feng Li, Fung-Chang Sung, Ming-Hsui Tsai, Chun-Hung Hua, Chiu-Shong Liu, Ru-Jiun Huang, Chih-Ching Yeh

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan, R.O.C.
2018-06-26; doi: 10.21873/anticanres.12771

Abstract

Aim

To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs).

Materials

A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines.

Results

A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes.

Conclusion

Our findings suggest that increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.