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Curcumin and Cinnamaldehyde as PTP1B Inhibitors With Antidiabetic and Anticancer Potential.

By: Tomasz Kostrzewa, Paulina Przychodzen, Magdalena Gorska-Ponikowska, Alicja Kuban-Jankowska

Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.
2018-11-20; doi: 10.21873/anticanres.13171

Abstract

Background/aim

Protein tyrosine phosphatase (PTP1B) is a potential target for the treatment of type 2 diabetes and cancer. Curcumin and cinnamaldehyde have been previously reported to have antidiabetic and anticancer potentials. The aim of this study was to investigate the effect of curcumin in comparison to cinnamaldehyde on the enzymatic activity of PTP1B and the viability of MCF-7 cancer cells.

Materials

Enzymatic activity and cell viability assays were utilized. Experiments were performed using the breast cancer MCF-7 cell line.

Results

Curcumin and cinnamaldehyde decreased the activity of PTP1B, and had inhibitory effects on the viability of MCF-7 cancer cells. Curcumin had a significantly higher inhibitory effect than cinnamaldehyde.

Conclusion

Curcumin can be considered a potential agent for the treatment of type-2 diabetes or cancer.