Despite the prevalence of prostate cancer worldwide, only a few risk factors have been well−established. The role of diet, especially of dairy products, in the etiology of prostate cancer is still controversial. »
03/15/10

Bevacizumab has recently been demonstrated to prolong overall survival when added to carboplatin and paclitaxel for chemotherapy−naA?ve patients with nonsquamous nonsmall−cell lung cancer (NSCLC). However, the effects of combining bevacizumab with other standard, front−line, platinum−based doublets have not been extensively explored. We designed this single treatment arm, phase 2 trial to determine whether the combination of carboplatin, docetaxel, and bevacizumab is tolerable and prolongs progression−free survival of chemotherapy−naA?ve patients with advanced, nonsquamous NSCLC. »
03/11/10

A study was undertaken to evaluate the clinical outcome of particle therapy for stage I nonsmall cell lung cancer (NSCLC). »
03/11/10

Cancer−associated fibroblasts (CAF) attract increasing attention as potential cancer drug targets due to their ability to stimulate, for example, tumor growth, invasion, angiogenesis, and metastasis. However, the molecular mechanisms causing the tumor−promoting properties of CAFs remain poorly understood. »
03/16/10

The authors investigated the expression of serum amyloid A (SAA) in endometrial endometrioid carcinoma and evaluated its potential as a serum biomarker. »
02/15/10

In the current study, we aimed to investigate the role of the long isoform of cellular Fas−associated death domain−like interleukin−1beta−converting enzyme (FLICE)−like inhibitory protein (c−FLIP(L)) in ovarian cancer (OC) development by using RNA interference (RNAi) in vitro and in vivo. »
03/12/10

p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may be associated with risk of SPMs and SPM−free survival among patients with squamous cell carcinoma of the head and neck (SCCHN). »
03/11/10

Gastrin−releasing peptide (GRP) receptors are overexpressed on a variety of human carcinomas, including those of the breast. These receptors may be targeted with bombesin (BBN), which binds to GRP receptors with high affinity and specificity. The aim of this study was to develop a (99m)Tc(I)−BBN analog with favorable pharmacokinetic properties in order to improve the visualization of breast cancer tissue. »
01/01/10

Many cancerous cells accumulate beta−catenin in the nucleus. We examined the role of epidermal growth factor receptor (EGFR) signaling in the accumulation of beta−catenin in the nuclei of oral cancer cells. »
03/19/10

High−resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification. Accurate biochemical assignment of small molecule metabolites that are "NMR visible" will improve our interpretation of HRMAS data and the translation of NMR tumour biomarkers to in vivo studies. »
03/23/10