We performed this study to evaluate the role of endobronchial ultrasound−guided transbronchial needle aspiration (EBUS−TBNA) in the pathologic diagnosis of lung cancer including lung masses as well as lymph nodes as targets. »
03/08/10

Substantial experimental evidence suggests that anticoagulants (ACs) may inhibit cancer growth and metastasis, although the limited data from clinical trials have been inconsistent. The potential antineoplastic effect of ACs was investigated in patients who received radiotherapy for localized prostate cancer. »
02/08/10

A study was conducted to determine the 5−year recurrence−free survival in patients with high−risk prostate cancer after neoadjuvant combination chemotherapy followed by surgery. Secondary endpoints included safety, pathologic effects of chemotherapy, and predictors of disease recurrence. »
02/08/10

Dissemination of prostate−specific antigen (PSA) testing in the United States coincided with an increasing incidence of prostate cancer, a shift to earlier stage disease at diagnosis, and decreasing prostate cancer mortality. »
02/08/10

Autophagy is a cellular process of degradation of macromolecules and organelles and activated under nutritional stress. Statins are a class of inhibitors of 3−hydroxyl−3−methylglutaryl coenzyme A (HMG−CoA) reductase, a key enzyme in synthesis of cholesterol. Epidemiological studies have shown that statin use decreases the incidence of advanced prostate cancer. We explored the idea that treatment of atorvastatin, a commonly prescribed statin for treatment of hypercholesterolemia, induces autophagy in prostate cancer cells. »
02/04/10

To investigate thymidylate synthase (TS) expression in primary colorectal cancer (CRC) as a prognostic and predictive marker of benefit for adjuvant chemotherapy. »
02/01/10

The aim of this study was to determine the antimetastatic efficacy of the combination of 5−fluorouracil (5−FU), leucovorin (LV), and irinotecan (CPT−11) (FOLFIRI) in an orthotopic nude mouse model of GFP−HCT−116 human colon cancer−expressing green fluorescent protein (GFP). »
02/01/10

Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion and progression of carcinogenesis. 5−Fluorouracil (5−FU) or 5−FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but produces an incomplete response resulting in survival of cells (chemo−surviving cells) that may lead to cancer recurrence. »
02/01/10

In this study, we investigated the inhibitive effects of Oplopanax horridus extract (OhE) and its fractions (OhF1, OhF2, OhF3, OhF4 and OhF5) on the growth of human colorectal cancer cells and the possible mechanisms involved were investigated. »
02/01/10

This study analyzed the possible prognostic value of presurgical serum soluble (s)E−selectin levels and/or carcinoembryonic antigen (CEA) mRNA positivity in predicting the disease−free survival of colorectal cancer (CRC) patients. »
03/24/10