Multidrug resistance poses a serious challenge in cancer therapy. To address this problem, we designed and synthesized Adva-27a, a novel non-ester GEM-difluorinated C-glycoside derivative of podophyllotoxin. »
01/13/13

Coumarin-based benzopyranone derivatives induced apoptosis in human lung (A549) cancer cells. »
01/13/13

Glucocorticoids are widely used for cancer patients, although they can reduce the efficacy of anticancer treatment. »
01/13/13

Data support the hypothesis that intakes of vegetables and fruit may significantly reduce the risk of ESCC »
09/03/12

Genetic amplication of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer. »
01/16/13

CEA to have the best sensitivity (93.7%) and specificity (96.1%) for colorectal cancer »
01/15/13

5-Fluoro-2'-deoxyuridine (5-FdU), a drug against gastric cancer, was covalently linked via its nucleobase with the amino-bisphosphonate alendronate (Ale), resulting in a new antimetabolite-bisphosphonate conjugate (5-FdU-Ale), designed for bone-targeting. »
10/13/12

miR-182 plays an onco-miRNA role in cervical cancer and its alteration is associated with cervical cancer »
10/18/12

Persistent infections with carcinogenic human papillomavirus (HPV) types are the necessary cause of cervical cancer. We recently demonstrated that the HPV16 genome is strongly methylated in cervical precancer compared with transient infections. However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood. »
10/23/12

Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models. »
01/15/13