Experimental data suggest that catecholamine hormones are involved in stimulating the aggressiveness of ovarian cancer, but few population-based studies have examined this association. We therefore conducted a population-based cohort study to examine whether Ss-blockers affect mortality following ovarian cancer diagnosis. »
02/22/13

Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2. »
02/22/13

OCT4 and BIRC5 are preferentially expressed in human cancer cells and mediate cancer cell survival and tumor maintenance. However, the molecular mechanism that regulates OCT4 and BIRC5 expression is not well characterized. »
02/22/13

Acute myeloid leukemia (AML) is a heterogeneous disorder with aberrant regulation of a variety of signal pathways. Therefore, simultaneous targeting of two or even more deregulated signal transduction pathways is needed to overcome drug resistance. Previously, it was reported that SNS-032, a selective cyclin-dependent kinase inhibitor, is an effective agent for treatment of AML; however, the molecular mechanisms of SNS-032-induced cell death of AML cells are not yet fully understood. The aim of the study was to characterize the effects in vitro of SNS-032, used alone and in combination with an Akt inhibitor perifosine, against AML cells and to identify the mechanism involved. »
02/18/13

YWHAZ has a pivotal role in gastric tumor cell proliferation through its overexpression. »
02/19/13

Novel breast cancer locus seen at the APOBEC3 genes »
02/16/13

MMP-14 targeting as an adjuvant treatment strategy for advanced ovarian cancer. »
02/21/13

TP expression is associated with more favorable prognostic factors (such as thin melanoma, low mitotic count). »
02/16/13

Increased odds of history of cervical cancer among subjects with MetS. »
12/21/12

Diet with higher total diet diversity and in particular fruit diversity may reduce the risk of bladder cancer. »
08/10/12