Glioblastoma multiforme (GBM) is the most aggressive type of glioma and carries the poorest chances of survival. There is therefore an urgent need to understand the mechanisms of glioma tumorigenesis and develop or improve therapeutics. The aim of this study was to assess the possible prognostic value of cyclin-dependent kinase 6 (CDK6) and the effects of microRNA-495 (miR-495) manipulation on CDK6 expression and cell survival in glioma cells. »
04/17/13

Breast cancer is a genetically and phenotypically complex disease. To understand the role of microRNAs (miRNAs) in this molecular complexity, we performed miRNA expression analysis in a cohort of molecularly well-characterized human breast cancer (BC) cell lines to identify miRNAs associated with the most common molecular subtypes and the most frequent genetic aberrations. »
04/19/13

Tumor-associated macrophages (TAM) promote malignant progression, yet the repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to analyze which EGFR- and STAT3-activating factors are secreted by monocytes/macrophages exposed to tumor cell-secreted factors. »
04/18/13

CPS is an inducer of ICD hallmarks, suggesting CPS as a novel potential immunogenic cytotoxic agent. »
02/11/13

Development of urinary bladder neoplastic lesions inhibited by meloxicam treatment. »
01/04/13

Role of oestrogen receptors in bladder cancer development. »
04/16/13

Gastric cancer stem cells: A novel therapeutic target. »
02/19/13

Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer. »
01/18/13

DNA methylation mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer. »
04/18/13

Recent evidence for and against the involvement of MMTV in human breast cancer »
01/27/13