Epigenetic control using histone deacetylase (HDAC) inhibitors is a promising therapy for lymphomas. Insights into the anti-proliferative effects of HDAC inhibitors on diffuse large B-cell lymphoma (DLBCL) and further understanding of the underlying mechanisms, which remain unclear to date, are of great importance. »
06/07/13

Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but its molecular mechanisms of pathogenesis are poorly understood. Our previous work has demonstrated that BCAT1 mRNA is over expressed in NPC and knocking down its expression in 5-8F NPC cell line can potently inhibit cell cycle progression and cell proliferation. However, the mechanism of BCAT1 up-regulation and its functional role in NPC development remain to be elucidated yet. »
06/08/13

Saquinavir, a protease inhibitor utilized in HIV infection, shows antitumor activity in various experimental models. In previous studies performed in our laboratory the drug was found to induce a substantial increase of telomerase activity in normal peripheral blood mononuclear cells. Aim of the present investigation was to test whether saquinavir was able to increase telomerase activity and the expression of the catalytic subunit of telomerase, hTERT, in human malignant hematopoietic cells. »
06/08/13

Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. »
02/17/13

Greater consumption of fruits and vegetables may lower the risk of invasive bladder cancer among women »
06/07/13

TGFalpha shedding is a key process driving EGFR activation and subsequent proliferation and invasion in triple-negative breast cancer cell lines. »
11/26/12

Dietary vitamin C intake before breast cancer diagnosis may be associated with breast cancer survival. »
06/04/13

The aim of this study was to clarify whether the evaluation of cell-cycle regulatory protein p27 can serve as a prognostic factor in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB cervical carcinoma. »
12/11/12

Several genes induced by PGK1 could account in colon cancer for cell migration, mainly EGR1 and CYR61 together with the transcription factors FOS and JUN. »
02/19/13

p16 is not a suitable biomarker for presence of HPV in hypopharyngeal tumor. »
06/21/12