Positive association between DM and risk of bladder cancer. »
11/05/13

Poly(adenosine diphosphate--ribose) polymerase 1 (PARP-1) and the balance between BRCA1 and 53BP1 play a key role in the DNA repair and cell stress response. PARP inhibitors show promising clinical activity in metastatic triple negative (TN) or BRCA-mutated breast cancer. However, a comprehensive analysis of PARP-1 activity, BRCA1 promoter methylation and 53BP1 expression in tumours without known BRCA1 mutation has not yet been carried out. »
11/05/13

Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA (protein) Napsin A was described to promote resistance to cisplatin by degradation of the tumor suppressor p53. »
11/05/13

TRAIL pathway and the regulators of apoptosis caspase-8, Bcl-xL and Mcl-1 in patients with HCC regarding patient survival. »
11/09/13

Functional significance of CYP2E1 in breast carcinogenesis. »
11/08/13

Potential involvement of autophagy in fluvastatin-induced cell death of lymphoma cells. »
11/08/13

Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. »
11/05/13

Serum OPN levels increased according to tumor pT classification and tumor size. »
11/11/13

CAIX, GLUT1, and CXCR4 showed profound lower expression rates in normal breast tissue. »
11/10/13

6-Shogaol is a promising antitumor agent isolated from dietary ginger (Zingiber officinale). However, little is known about the efficacy of 6-shogaol on leukemia cells. Here we investigated the underlying mechanism of 6-shogaol induced apoptosis in human leukemia cells in vitro and in vivo. »
11/12/13