Its oncogenic role was dependent on targeting PTEN. »
05/13/14

HPN is associated with an improvement in QoL and nutritional status in advanced cancer patients. »
08/15/14

The anti-proliferative effects of PEITC in hCSCs may at least partially result from up regulation of DR4. »
08/15/14

Inhibitors of PI3K/mTOR and GLI signaling reduced neuroblastoma cell growth. »
08/18/14

MMP-9 overexpression revealed itself as startling feature of triple-negative and HER2-positive breast cancers. »
08/23/14

No significant association found between RBC folate and breast cancer. »
08/18/14

Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines. »
08/20/14

Survivin is a protein that is normally present only in G2 and M-phases in somatic cells, however, in cancer cells, it is expressed throughout the cell cycle. A prosurvival factor, survivin is both an inhibitor of apoptosis and an essential mitotic protein, thus it has attracted much attention as a target for new oncotherapies. Despite its prevalence in cancer, reports of survivin mutations have mostly been restricted to loci within its promoter, which increase the abundance of the protein. To date the only published mutation within the coding sequence is an adenine¿>¿guanine substitution in exon 4. This polymorphism, which was found in a cohort of Korean lung cancer patients, causes a lysine¿>¿glutamic acid mutation (K129E) in the protein. However, whether it plays a causative role in cancer has not been addressed. »
08/19/14

Aberrant DNA methylation is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor genes and other genes in diverse human cancers. Gastric carcinoma is one of the tumors with a high frequency of aberrant methylation in promoter region. Hence we investigated the promoter methylation status and expression level of HOXA11 gene which may involve in GC development. »
08/19/14

Plasma exosomal miR-1290 and miR-375 are promising prognostic biomarkers for CRPC patients. »
05/08/14