Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in Third World countries. In this study, the cytotoxicity of a third-generation oncolytic HSV, G47¿, was investigated in different human HCC cell lines and in an immortalized human hepatic cell line. Additionally, subcutaneous models of HCC were established to evaluate the in vivo anti-tumor efficacy of G47¿. »
09/19/14

Demand for BRCA1/2 testing almost doubled and there were also many more enquiries for risk reducing mastectomy. »
09/19/14

Gene promoter hypomethylation as a distinctive subtype-specific mechanism for controlling the expression of a key regulator of Rac-mediated motility. »
09/24/14

Inactivation of TLR4/NF-κB signaling inhibited the mRNA and protein expression of CXCR4. »
09/23/14

High levels of HGF protein in tumor tissues correlated with lower levels of RIPK1 and shorter survival times of patients. »
03/19/14

High consumption of processed meat probably correlated with rising risk of bladder cancer. »
09/29/14

VD use was associated with improved DFS.  »
04/22/14

Adding EVE to EXE did not confer a statistically significant improvement. »
09/19/14

NEDD9 directly binds to Arf6-GTPase-activating protein, ARAP3. »
04/28/14

F10 displays strong efficacy for GBM treatment with minimal toxicity. »
07/02/13