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Found 15815 articles
Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study.
Biopsy-verified localization of BMTP-11 to tumors in the bone marrow and drug-induced apoptosis demonstrated.
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09/09/14
17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation.
17-DMCHAG treatment damaged the Hsp90/AR and Hsp90/survivin complexes.
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12/19/14
NUAK2 amplification coupled with PTEN deficiency promote melanoma development via CDK activation.
CDK2 blockade may offer a promising therapy for genetically-defined melanomas.
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04/03/15
Targeting SLC1A5-mediated glutamine dependence in non-small cell lung cancer.
Inactivation of SLC1A5 genetically or pharmacologically decreased Gln consumption, inhibited cell growth, induced autophagy and apoptosis.
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02/17/15
Antiproliferative effects of β-blockers on human colorectal cancer cells.
The results suggested that adrenergic activation plays an important role in colon cancer cell proliferation.
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09/12/14
HDAC inhibition overcomes acute resistance to MEK inhibition in BRAF mutant colorectal cancer by down-regulation of c-FLIPL.
Combined HDAC inhibitor/MEKi treatment resulted in dramatically attenuated tumor growth in BRAFMT xenografts.
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03/28/15
Effect of REG Iα protein on angiogenesis in gastric cancer tissues.
Treatment with REG Iα protein promoted growth and anti-apoptosis through activation of the ERK and Akt signaling pathways.
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12/31/14
FoxM1 drives a feed-forward STAT3 activation loop that promotes self-renewal and tumorigenicity of glioblastoma stem-like cells.
FoxM1 activates expression of PDGF-A and STAT3.
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04/03/15
Quantitative DNA methylation analysis of candidate genes in cervical cancer.
Alterations in DNA methylation of specific genes in cervical cancers, such as DAPK1, RARB, WIF1, and SLIT2.
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04/02/15
PI3K/AKT pathway-mediated regulation of p27(Kip1) is associated with cell cycle arrest and apoptosis in cervical cancer.
p27(Kip1) down-regulation in cervical cancer cells is primarily regulated through PI3K/AKT-mediated proteasomal degradation.
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03/11/15
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